PT  - JOURNAL ARTICLE
AU  - Camilo Corbellini
AU  - Saverio Tavella
AU  - Elisa Gugliotta
AU  - Stefano Zampese
AU  - Eleuterio A. Sanchez Romero
AU  - Jorge Villafane
TI  - HYPERCAPNIA AND FUNCTIONAL IMPROVEMENTS DURING PULMONARY REHABILITATION
AID  - 10.1183/13993003.congress-2021.PA1827
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA1827
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA1827.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA1827.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Hypercapnia is a relevant and frequent clinical issue that compromises functional status in stable and acute COPD subjects. Pulmonary rehabilitation (PR) aims, but not exclusively, to improve hypercapnia and hypoxemia. The aim of this study is to measure whether inpatient PR improves Partial Arterial Carbon Dioxide Pressure (PaCO2) and functional outcomes in hypercapnic and normocapnic COPD subjects. We hypothesize that subjects who improve functional status will also present improvements in PaCO2.Methods: Prospective cohort of moderate to very severe COPD subjects who underwent inpatient PR according to the ERS/ATS statement at CASA DI CURA VILLA SERENA, Piossasco, Italy. All individuals followed an assessment protocol that comprised a six-minute walk test, gait speed tests, lung function tests, and blood gas analysis. Student T-test and Bonferroni test were used in the analysis.Results: We screened 546 subjects from January 2018 to December 2020, who completed the PR protocol. Mean FEV1 45±26 (%pred). Table 1 shows improvements regarding walked distance and PaCO2, in hypercapnic (n= 135) and normocapnic (n= 385) subjects. It was excluded 26 hypocapnic patients. Both groups presented improvements in the walked distance. Hypercapnic subjects reduced significantly and clinically the PaCO2 level.Conclusions: PR other than the known functional improvements improves PaCO2 levels in hypercapnic patients.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1827.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).