RT Journal Article
SR Electronic
T1 Aerobic Training Improves Pulmonary and Systemic Inflammatory and Fibrotic Response in Asthmatics
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA2935
DO 10.1183/13993003.congress-2021.OA2935
VO 58
IS suppl 65
A1 Moraes Ferreira, Renilson
A1 A R Brandao-Rangel, Maysa
A1 Silva-Reis, Anamei
A1 G Gibson-Alves, Thiago
A1 C Aquino-Santos, Helida
A1 H Souza-Palmeira, Victor
A1 R Frison, Claudio
A1 P Vieira, Rodolfo
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/OA2935.abstract
AB Airway remodeling is a hallmark of asthma driven by non-resolved chronic inflammatory response, beyond exacerbated release of pro-fibrotic mediators. Aerobic exercise (AE) improves asthma management and airway inflammation, but its effects on pulmonary and systemic cellular and humoral immune response are unknown. Treadmill aerobic exercise (AE) (12 weeks, 3x/week, 40min/session, 60-80%MaxHR) was applied to 17 persistent moderate asthmatic patients (42.11±19.13). Body mass index (BMI), lung function, induced sputum, breath condensate, whole blood analysis and CD4+ cells proliferation, 6MWT, exhaled nitric oxide, was evaluated. AE improved VEF3 (L) (p&lt;0.03) and PEF (L/min) (p&lt;0.005) and PEF (%) (p&lt;0.004), reduced the number of total leukocytes, eosinophils, neutrophils, lymphocytes and macrophages (p&lt;0.01), as well as the levels of IL-1beta, IL-4, IL-5, IL-6, IL-8, IL-13, IL-17, IL-23 (p&lt;0.01) in induced sputum. AE also reduced the levels of IL-1beta, IL-5, IL-6, IL-13, VEGF (p&lt;0.01), while increased the levels of anti-inflammatory IL-1ra and IL-10 (p&lt;0.01) and anti-fibrotic Relaxin 3 (p&lt;0.01) in breath condensate. Systemically, AE reduced the number of eosinophils, neutrophils and lymphocytes (p&lt;0.01), as well as the levels of IL-1beta, IL-5, IL-6, IL-13, VEGF (p&lt;0.01), while increased anti-inflammatory IL-1ra, IL-10 (p&lt;0.01) and anti-fibrotic Relaxin 3 (p&lt;0.01) in plasma. AE improved 6MWT (p&lt;0.01) and reduced exhaled nitric oxide (p&lt;0.01) and CD4+ cells proliferation (p&lt;0.01). AE improves airway and systemic inflammation reducing pro-inflammatory cytokines, while increased anti-inflammatory and anti-fibrotic mediators systemically and into the lungs.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2935.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).