RT Journal Article
SR Electronic
T1 ACCURACY OF COPD SCREENING STRATEGIES AMONG HYPERTENSIVE PATIENTS IN BRAZIL: A BREATHE WELL STUDY
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3639
DO 10.1183/13993003.congress-2021.PA3639
VO 58
IS suppl 65
A1 SONIA MARTINS
A1 Andrew Dickens
A1 William Salibe-Filho
A1 Luis Sousa
A1 Aldo Albuquerque-Neto
A1 Peymane Adab
A1 Alexandra Enocson
A1 Alice Sitch
A1 Rafael Stelmach
A1 Rachel Jordan
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3639.abstract
AB Background:COPD and hypertension are often concomitant diseases, although undiagnosed COPD is common in Brazil and the optimal strategy to identify new cases is unclear.Aims: To evaluate the accuracy and cost-effectiveness of COPD screening strategies amongst hypertensive patients in Brazil.Methods: Test accuracy study conducted in 9 Basic Health Units. Participants completed 6 index tests (CDQ, CAPTURE, COPD-SQ, symptom based questionnaire [SBQ], microspirometry [COPD-6], peak flow [Mini Wright]) and the reference test (ndd Easy-On PC and clinical review). Cases were defined as below lower limit of normal (LLN-GLI) with clinically confirmed symptoms. Performance of all index tests and strategies was evaluated, with specificity being prioritised. Cost effectiveness analysis will be presented at the conference.Results: 1162 participants (mean age 62.3 [SD10.1] years, 32.5% [n=378] male) completed the study; 49.1% (n=570) were never smokers and 9.8% (n=114) had an existing COPD diagnosis. 79 participants (6.8%) were confirmed cases after clinical review. Airflow measurement devices (sensitivities 44.3% and 50.6%,specificity 95.5% and 87,2% for peak flow and microespirometry respectively) generally had better specificity than questionnaires, the most accurate of with was SBQ (sensitivity 75.9%, specificity 59,2%). For combinations requiring both tests to be positive, SBQ and peak flow maximised specificity(97.0%) with sensitivity of 39.2%.Conclusion: The peak flow was the best performing airflow measurement device, SBQ the best questionnaire, and the combination of SBQ and peak flow the most accurate strategy. Different cut-points need to be explored to optimise use in practice.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3639.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).