TY - JOUR T1 - Prospective 3D echocardiographic analysis of RV remodeling and contracility in PH Patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA1933 VL - 58 IS - suppl 65 SP - PA1933 AU - Timothee Lambert AU - Bouchra Lamia AU - Angelique Picard AU - Mathilde Azzi AU - Fatoi Bidar AU - Philippe Bonnet AU - Bouchra Lamia Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA1933.abstract N2 - Introduction: Right ventricular (RV) function including RV remodeling and RV contractility play a key role in the prognosis of pulmonary hypertension (PH) patients. Three dimensional (3D) echocardiograhy has been recently improved to assess RV ejection fraction and volumes.We analyzed right heart (RH) function in PH patients using 3D echo at baseline and during follow-upMethods: All patients prospectively underwent a right heart catheterization (RHC) and 3D echocardiography within one hour.Results: 36 patients (15 women; 21 mean; age 69 ± 11) were included. At baseline, mPAP was 41 ± 12 mmHg, cardiac index (CI) was 2.9 ± 0.9 L/min/m2, pulmonary capillary wedge pressure was 11 ± 4 mmHg, right atrial pressure (RAP) was 14 ± 6 mmHg, pulmonary vascular resistance (PVR) was 7 ± 4 WU. At baseline RVEF was decreased 40 ± 13% (normal value : 58 ± 6% and abnormality threshold < 45%), RVFAC as well : 34 ± 13% whereas TAPSE was slightly decreased and 20± 5%RV remodeling analysis showed dilated RV: RV/Left Ventricule area = 1 ± 0.6 (normal <0.6). Using univariate analysis RVEF was significantly correlated to mPAP, PVR, RV size, TAPSE (r²=0.14 ; p=0.0363), DTI S wave (r²=0.2 ; p=0.0135) and global strain (r²=0.57 ; p=0.0002). Using multivariate analysis RVEF was significantly correlated to TAPSE (p=0.0243) and strain global (p=0.0007). Ten patients (31%) had decreased RVEF while TAPSE remained normal. In patients treated with pulmonary vasodilators (n=12) who had RHC and 2D and 3D echo analysis during follow up RVEF increased from 32 ± 12% to 42 ± 4% while TAPSE remainded stable 20 ± 6% to 21 ± 5%Conclusion: ThreeD-Echo RVEF seems to be useful as an early parameter of RV systolic dysfunctionFootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1933.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -