%0 Journal Article %A Juan Pablo López-Cervantes %A Rajesh Shigdel %A Tehmina Mustafa %A Cecilie Svanes %T Does parental tuberculosis infection increase the risk of asthma in their offspring? A Norwegian registry-based study %D 2021 %R 10.1183/13993003.congress-2021.PA824 %J European Respiratory Journal %P PA824 %V 58 %N suppl 65 %X Introduction: The links between early life infections with asthma and allergies have been extensively studied, however, previous work is limited to a one-generation setting. Murine models suggest infections may impact on immunity in future offspring.Aim: To study the impact of parental tuberculosis infection prior to conception on asthma and rhinitis in their offspring.Methods: We included 16 057 offspring (mean birth year 1968) registered in the Norwegian Prescription Database (NorPD), of 10 300 parents with a history of tuberculosis (mean age at diagnosis, 45.2 years), included in the Norwegian Tuberculosis Registry (1962-2010). Asthma (n=3657) and rhinitis (n=3873) were defined by diagnosis + type of medication + prescribed medication ≥1 year. The association of parental tuberculosis in age windows <8 years, 8-15 years, >15 years but before conception, and after birth (reference category), with offspring asthma and rhinitis, was analyzed using logistic regression adjusted for parent´s sex and offspring´s sex, birth year and tuberculosis.Results: The risk of asthma in offspring was higher in those with parental tuberculosis <8 years as than in those with parental tuberculosis after their birth (odds ratio 1.40; 95% confidence interval 1.13-1.72). Significant associations with offspring rhinitis were not identified.Conclusions: Parental tuberculosis infection in childhood was associated with higher risk of asthma in their future offspring. We speculate that tuberculosis may have profound impact that may be transferred to offspring, the nature of such impact needs further study.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA824.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U