PT  - JOURNAL ARTICLE
AU  - Natália Campos
AU  - Fernanda Vendrusculo
AU  - Ingrid Almeida
AU  - Nicolas Becker
AU  - Leonardo Pinto
AU  - Márcio Donadio
TI  - Correlation of the Brody high resolution computed tomography scoring system with aerobic fitness and lung function in patients with cystic fibrosis
AID  - 10.1183/13993003.congress-2021.PA3369
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA3369
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA3369.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA3369.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: Patients with cystic fibrosis (CF) present airway obstruction leading to permanent structural lung damage, which may contribute to the decline in lung function and exercise intolerance.Aims: To evaluate the correlation between the Brody tomographic scoring system with aerobic fitness and lung function variables.Methods: Cross-sectional study including patients with a diagnosis of CF aged ≥6 years. All subjects underwent lung function (spirometry), cardiopulmonary exercise testing (CPET), and a high resolution computed tomography test in order to calculate the Brody score, following the ATS/ERS recommendations. A Pearson correlation test was used for statistical purposes. The study was approved by a research ethics committee.Results: Nineteen patients (63,2% male), mean age 13.9±5.2 years, were included. A mean forced expiratory volume in the first second (FEV1) of 78.3±27.7%, peak oxygen consumption of 35.7±6.2 mL.kg-1.min-1 and Brody score of 42.0±26.7 were found, describing a sample of mild-to-moderate lung impairment. As for aerobic fitness, an inverse and moderate correlation was found between peripheral oxygen saturation at peak exercise and the Brody score (r=-0.57, p=0.01), indicating that patients with the worst tomographic score presented more desaturation during exercise. Lung function also correlated inversely and moderately with the Brody score (forced vital capacity: r=-0.48, p=0.04; FEV1: r=-051, p=0.03).Conclusion: The Brody score correlates with both oxygen desaturation at peak exercise and lung function, highlighting the influence of structural lung damage on lung function impairment and exercise intolerance.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3369.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).