RT Journal Article
SR Electronic
T1 Late Breaking Abstract - Relationship between clinical features and mortality in a cohort of COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3842
DO 10.1183/13993003.congress-2021.PA3842
VO 58
IS suppl 65
A1 Paolo Solidoro
A1 Fulvio Braido
A1 Marco Contoli
A1 Angelo Corsico
A1 Fabiano Di Marco
A1 Claudio Micheletto
A1 Girolamo Pelaia
A1 Paola Rogliani
A1 Laura Saderi
A1 Nicola Scichilone
A1 Giovanni Sotgiu
A1 Giandomenico Manna
A1 Silvia Boarino
A1 Pierachille Santus
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3842.abstract
AB Background: Chronic obstructive pulmonary disease (COPD) is a progressive disease with poor outcomes, including a high mortality. GULP is a multicenter Italian study that described clinical characteristics, exacerbation rates and survival of a cohort of COPD patients, as part of AstraZeneca’s AvoidEX program.Aims and objectives: To evaluate whether the clinical profile of subjects enrolled in the GULP study predicts mortality on a period of 3 years.Methods: Post-hoc analysis of an observational, multicenter, retrospective study. Patients were stratified according to survival status: alive (A) and dead (D). Clinical characteristics, comorbidities and exacerbation rates were reported in the two groups. Mortality was assessed at 3 years from the index visit.Results: 859 patients were included in the analysis, of whom 745 belonged to group A (73.7% male, median (IQR) age 76 (70-81), median (IQR) BMI 26.7 (23.7-29.4), median (IQR) FEV1 1.410 L (990-1.880), 14.2% chronic heart failure, 17.3% ischemic heart disease) and 154 to group D (76.3% male, median (IQR) age 80 (74-84), median (IQR) BMI 25.5 (22.7-29.0), median (IQR) FEV1 1.140 L (820-1.670), 27.2% chronic heart failure, 28.1% ischemic heart disease). More patients in the D group experienced ≥1 exacerbation (23.5%, 24 events VS. 10.2%, 73 events, respectively; p-value: 0.002). Chronic heart failure and ischemic heart disease were associated with a higher odds ratio (OR) of mortality (OR: 2.2, p-value: 0.001; OR: 1.9, p-value: 0.007; respectively).Conclusions: COPD patients enrolled in the GULP study showed high prevalence of cardio-vascular diseases. Chronic heart failure and ischemic heart disease appeared to predict mortality in this cohort.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3842.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).