RT Journal Article
SR Electronic
T1 Visceral Fat is More Related to Impairment of Lung Function and Mechanics and Pulmonary Immune Response in Overweight and Grade I Obese Women
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3305
DO 10.1183/13993003.congress-2021.PA3305
VO 58
IS suppl 65
A1 Anamei Silva-Reis
A1 Maysa A Rodrigues Brandao-Rangel
A1 Renilson Moraes-Ferreira
A1 Thiago G Gonçalves-Alves
A1 Victor H Souza-Palmeira
A1 Helida C Aquino-Santos
A1 Claudio R Frison
A1 Rodolfo P Vieira
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3305.abstract
AB Beyond the common comorbidities related to obesity, such as type 2 diabetes and cardiovascular diseases, impaired lung function is already known, but, whether the fat distribution (sub-cutaneous, abdominal, visceral) affects the lung function and pulmonary immune response are poorly known. Visceral fat is associated with insulin resistance and low-grade inflammation and reduced lung function. In the present study, the body composition and fat distribution was evaluated by multi-frequency octopolar bioimpedance. So, this study demonstrated a correlation of increased visceral fat with impaired lung function in obesity grade I (n=28; 45.46±10.38 years old) women, which has not been observed in eutrophic (n=20; 43.20±10.78 years old) and in overweight (n=30; 47.27±10.25 years old) women. Also, we identified a negative correlation in FVC% (R2=0.9129; p<0.0236), FEV1% (R2=0.1079; p<0.0134), PEF% (R2=0.1673; p<0.0018) and VC IN% (R2=0.1330; p<0.0057) in the grade I obesity group, clearly demonstrating that higher levels of visceral fat correlate with reduced lung function, but not with sub-cutaneous or abdominal fat. In addition, it was observed for the first time a negative correlation among anti-fibrotic protein Klotho (R2=0.09298; p<0.0897) and anti-inflammatory IL-10 (R2=0.1653; p<0.0487) in plasma, so, contrarily to increased visceral fat. On contrary, in breath condensate, a positive correlation for Adiponectin (R2=0.5665; p<0.0120), IL1-Ra (R2=0.2121; p<0.0544) and IL1-Beta (R2=0.3270; p<0.0084) was found. Thus, increased visceral fat directly influences impairment of lung function and of systemic and pulmonary immune response of obese womenFootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3305.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).