RT Journal Article
SR Electronic
T1 External oxidants and asthma in childhood
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3079
DO 10.1183/13993003.congress-2021.PA3079
VO 58
IS suppl 65
A1 Emilija Vlashki
A1 Valentina Cvejoska Cholakovska
A1 Mica Kimovska
A1 Tara Ristevska
A1 Joshua Lawson
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3079.abstract
AB Aim: The aim of this study was to examine the impact of external oxidants on childhood asthma in The Republic of North Macedonia, as a country with a high Acetaminophen use, air pollution and dietary antioxidant intake, and a low prevalence of asthma.Methods: Parental-reported data obtained through a survey of 2310 children 5-15 year of age from randomly selected schools in Skopje, the capital of Macedonia, was used. The impact of current Acetaminophen use, frequency of trucks passage through the residential street, environmental tobacco smoke (ETS) and coal/wood heating at home were all correlated to current asthma symptoms and ever-diagnosed asthma after adjustments for potential confounders using multiple logistic regression.Results: The prevalence of current Acetaminophen use was 72.6%, of ETS was 28.2%, of coal/wood heating was 8.2%, and of trucks passage almost the whole day was 9.4%. Current wheeze was documented in 6.5%, current sleep-disturbing wheeze in 3.6%, current dry night cough in 12.2%, and asthma in 2.3% of the children. Current Acetaminophen use as well trucks passage almost the whole day increased the risk of current wheeze (aOR: 2.94; 1.72-5.02 and aOR: 3.31; 1.58-6.93, respectively), sleep-disturbing wheeze (aOR: 1.93; 1.03-3.63 and aOR: 5.61; 1.84-17.15, respectively), and dry night cough (aOR: 1.47; 1.06-2.05 and aOR: 1.87; 1.06-3.30, respectively).Conclusion: The findings support the adverse effect of external oxidants, such as Acetaminophen and outdoor air pollutants, on current asthma symptoms. Although Acetaminophen remains a preferred analgesic and antipyretic in childhood, its frequent use should be cautioned, and exposure to outdoor air pollution should be reduced to contribute in asthma prevention.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3079.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).