RT Journal Article
SR Electronic
T1 A comparison of 129Xe MRI and advanced lung function testing in patients with asthma and /or COPD: The NOVELTY ADPro substudy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1872
DO 10.1183/13993003.congress-2021.PA1872
VO 58
IS suppl 65
A1 Marshall, Helen
A1 Smith, Laurie
A1 Biancardi, Alberto
A1 Collier, Guilhem
A1 Chan, Ho-Fung
A1 Hughes, Paul
A1 Astley, Joshua
A1 Munro, Ryan
A1 Rajaram, Smitha
A1 Capener, Dave
A1 Bray, Jody
A1 Smith, Ian
A1 Armstrong, Leanne
A1 Hardaker, Latife
A1 Fihn-Wikander, Titti
A1 Hughes, Rod
A1 Wild, Jim
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA1872.abstract
AB Introduction: A substantial proportion of patients with obstructive lung disease have clinical features of both asthma and COPD. 129Xe MRI is highly sensitive to lung function and may be able to assist in phenotyping patients.Objective: To investigate relationships between 129Xe MRI and pulmonary function test metrics in patients with asthma and/or COPD.Methods: 50 patients with asthma and/or COPD taking part in the NOVELTY study (NCT02760329, Reddel HK et al ERJ Open Res 2019 5(1):00036-2018) were recruited from 2 primary care centres. Patients were assessed with 129Xe MRI (ventilation, acinar microstructure and gas exchange) and pulmonary function tests.Results: 129Xe MRI ventilation, acinar dimension and gas exchange metrics showed moderate-to-strong correlations with spirometry and TLCO, and with each other. Example images are shown in fig 1.VDP correlated strongly with FEV1/FVC and lung clearance index, and weakly with R20 and AX. RBC/gas and acinar airway dimensions correlated strongly with TLCO.Conclusion: Preliminary MRI analyses show reduced ventilation, increased acinar airway dimensions and reduced gas transfer ratios with increasing disease severity (decreased spirometry and TLCO) in a broadly defined group of patients with asthma and/or COPD, consistent with airway obstruction, enlarged alveolar airspaces, reduced alveolar-capillary barrier thickness and reduced gas transfer.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1872.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).