RT Journal Article
SR Electronic
T1 Determinants of blood eosinophil count in adults from a large population-based study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1152
DO 10.1183/13993003.congress-2021.PA1152
VO 58
IS suppl 65
A1 Rita Amaral
A1 Tiago Jacinto
A1 Andrei Malinovschi
A1 Christer Janson
A1 David Price
A1 João Fonseca
A1 Kjell Alving
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA1152.abstract
AB Factors not associated with respiratory disease that influence blood eosinophil (B-Eos) count have not been clearly defined. We aimed to evaluate the influence of non-respiratory diseases on B-Eos count and to identify individual characteristics, including gender and body mass index, associated with B-Eos count in individuals without respiratory disease.Individuals (18-85 years) with complete B-Eos data from the US National Health and Nutritional Examination Surveys 2005–2016 were grouped as having respiratory disease (n=7,894) or not having respiratory disease (n=15,010). Among those without respiratory disease, non-respiratory diseases that were independently associated with B-Eos count were obtained by multivariate linear regression. After excluding significant non-respiratory diseases, independent associations between individual characteristics and B-Eos count were analysed in 5,667 healthy controls.Having metabolic syndrome, heart disease and stroke were associated with 12%, 13%, and 15% higher B-Eos count, respectively (p<0.001 for all). In healthy controls, male sex and obesity were associated with higher B-Eos counts (14% and 19% higher, respectively) (p<0.01 both), while age was not a significant determinant (p=0.290). Also, current smokers had 17% higher B-Eos counts than never smokers (p<0.001).Non-respiratory diseases influence B-Eos count in adults without respiratory disease from the general population. Male sex, obesity, and current smoking, but not age, were individual characteristics or exposures that were associated with higher B-Eos level. These factors should be considered when using B-Eos count in the management of respiratory diseases.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1152.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).