RT Journal Article SR Electronic T1 CAPTAIN: Effects of lung function at screening (FEV1 % predicted) as a continuous variable on treatment outcomes JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA1487 DO 10.1183/13993003.congress-2021.OA1487 VO 58 IS suppl 65 A1 Alberto Papi A1 Neil Barnes A1 Andrew Fowler A1 Huib Kerstjens A1 Edward Kerwin A1 David Mannino A1 Robert Nathan A1 Ian Pavord A1 Emillio Pizzichini A1 David Slade A1 Agne Zarankaite A1 John Oppenheimer YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/OA1487.abstract AB Background: In patients with uncontrolled asthma despite ICS/LABA, effects of adding LAMA or increasing ICS may vary by lung function at screening.Aim: Investigate whether lung function at screening predicts response to adding UMEC or increasing FF dose.Methods: CAPTAIN: Phase IIIA, randomised, double-blind, 24–52-week, parallel-group study in adults with uncontrolled asthma. Treatment: FF/VI (100/25, 200/25μg) or FF/UMEC/VI (100/31.25/25, 100/62.5/25, 200/31.25/25, 200/62.5/25μg) QD (ELLIPTA). Outcomes: change from baseline in trough FEV1 (Wk 24), annualised moderate/severe exacerbation rate (Wks 1–52), by FEV1 % predicted at screening (post hoc analyses).Results: Numerically greater improvements in trough FEV1 were seen with adding UMEC or increasing FF, across the FEV1 % predicted range (Fig 1); adding UMEC led to greater improvements than increasing FF. Similarly, numerically greater reductions in exacerbation rate were seen with increasing FF; adding UMEC had minimal impact (Fig 2).Conclusions: Effects of adding UMEC or increasing FF were largely independent of lung function at screening.Funding: GSK (205715/NCT02924688)FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA1487.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).