PT  - JOURNAL ARTICLE
AU  - Khalil Bahri
AU  - Samira Mhamdi
AU  - Selsabil Daboussi
AU  - Asma Riahi
AU  - Imene Yousfi
AU  - Islem Mejri
AU  - Chiraz Aichaouia
AU  - Ziad Moatamri
AU  - Mohsen Khadhraoui
TI  - Covid-19 and pulmonary embolism : A heterogeneous association
AID  - 10.1183/13993003.congress-2021.PA502
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA502
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA502.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA502.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Introduction: Covid-19 pneumonia has been shown to be associated with an increased prevalence of pulmonary embolism (PE) and along with it, an expected higher risk of morbidity and mortality.Aim: Identifying risk factors for PE and eventual prognosis relating to these factors.Methods: 139 patients were admitted to the military hospital of Tunis, positive on covid-19 RT-PCR testing, from September 2020 to February 2021.Results: Out of those patients,12 (11.8%) had a pulmonary embolism confirmed by CT-angiography.There was no significant correlation between PE and gender, history of pulmonary disease (asthma and COPD), or cardiovascular risk factors (type-2 diabetes, hypertension, dyslipidemia).There was a statistically significant difference between Hemoglobin serum levels in the PE positive group vs the PE negative group(11,66 g/dL vs 13,01 g/dL, p-value 0,22).This was also the case for prothrombin ratio which was lower in the PE positive group than in the negative group(79,5% vs 90,32%, p-value 0,39).Mean D-dimer, measured on admission, was not significantly higher in the PE positive group (5052 ng/mL) than the PE negative group(2404 ng/mL), similarly to C-reactive protein levels(129,12 mg/L vs 152,7mg/L).No significant correlation was found between PE, fibrinogen and ferritinemia serum levels.On CT-scans, out of 12 patients, 5 had a 25-50% lesion extent,3 had 50-75% and only 1 had >75% while the rest were not siginificant.PE was not associated with a worst outcome:no patients needed optiflow or intubation during admission and there was no significant difference in death between the two groups.Conclusion: These findings give another perspective on PE in the context of covid-19 and emphasize the heterogeneity of its induced coagulopathy.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA502.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).