TY - JOUR T1 - Thromboembolic events in COVID-19 patients : A Tunisian case series study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3812 VL - 58 IS - suppl 65 SP - PA3812 AU - Sabrine Louhaichi AU - Mariem Ferchichi AU - Ikbelle Khalfallah AU - Safa Belkhir AU - Nouha Boubaker AU - Jamel Ammar AU - Besma Hamdi AU - Agnès Hamzaoui Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3812.abstract N2 - Coronavirus disease 2019 (COVID‐19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospital was conducted. We compared the characteristics of 2 groups: patients with TC and patients without TC.The median age was 64,9±13,5 [22– 98] years and 65% were men. A total of 26(13%) patients required intensive care. The most comon comorbidities were hypertension(46%),diabetes(40%) and obesity(32%).The incidence of TC was 22%(44/200).Pulmonary embolism was confirmed in 21 patients, and deep venous thrombosis was confirmed in 9 patients. Acute limb ischemia, acute coronary syndrome and ischemic stroke were observed in 4.5%,1.5% and 1% respectively. Thrombotic events occured within 4,7±2,1 days of hospital admission. Besides ICU stay(p=0,02),other risk factors associated with TC in univariable regression analyses were higher neutrophil‐to‐lymphocyte ratio (p=0,04),and a higher D‐dimer level (p=0,002).TC appeared to be associated with death (p<0.001).Thrombotic complications in Covid 19 are associated with poor prognosis. The increase of D-dimer level and the higher neutrophil‐to‐lymphocyte ratio seems to be good index for identifying high-risk groups of TC.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3812.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -