RT Journal Article
SR Electronic
T1 Pulmonary involvement in antisynthetase syndrome: more than myopathy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3298
DO 10.1183/13993003.congress-2021.PA3298
VO 58
IS suppl 65
A1 Çiftci, Fatma
A1 Süslü, Sema Nur
A1 Kayacan, Oya
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3298.abstract
AB Antisynthetase syndrome (ASS) is a rare CTD. Pulmonary involvement is the most important guide in predicting prognosis. While investigating the etiology of ILD in the chest diseases outpatient clinic, the characteristics of three subjects diagnosed with ASS were examined (Figure).NSIP was observed in two cases and organized pneumonia in one. Serum autoantibodies were positive against aminoacyl transfer RNA synthetases. Lymphocytosis was observed in BAL. All of them were evaluated by the multidisciplinary team and immunosuppressive therapy was initiated for the patients. Clinical and radiological improvement was detected in all cases during follow-up. Unfortunately Case 2 died in the 3rd year of his follow-up due to metastatic colon adenocancer.ASS is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud's phenomenon, mechanic’s hand, ILD, and serum autoantibodies to aminoacyl transfer RNA synthetases. NSIP and organizing pneumonia are the most common forms of ILD. The prognosis is poor in the presence of ILD. It should be kept in mind that the high risk of malignancy in these cases.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3298.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).