TY - JOUR T1 - Mortality risk in a Romanian cohort of patients hospitalised for COVID-19 JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3815 VL - 58 IS - suppl 65 SP - PA3815 AU - Stefan-Marian Frent AU - Andras Bikov AU - Emanuel Bobu AU - Roxana Pleava AU - Costela Serban AU - Iosif Marincu AU - Monica Marc AU - Stefan Mihaicuta AU - Cristian Oancea Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3815.abstract N2 - Introduction: The incidence of poor outcomes in patients diagnosed with Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is relatively high. We aimed to identify risk factors associated with increased mortality in patients hospitalised for COVID-19 in a university hospital from Western Romania.Methods: In this observational, single center study, we included consecutive patients admitted with a COVID-19 diagnosis in the Pulmonology Department of Victor Babes Hospital Timisoara, Romania. Clinical data including patient characteristics and outcomes, as well as laboratory, imaging and treatment data were collected. A multivariate logistic regression model was used to identify predictors of mortality.Results: 146 patients (age 61.1±13.7) hospitalised for COVID-19 between August and October 2020 were included in the study. Overall mortality was 15.8% (23 patients). Fatal outcome was associated with male gender (p=0.047), older age (p<0.001), lower oxygen saturation (SaO2) at admission (p=0.012), higher CRP level (p=0.001) and higher extension of pulmonary lesions on CT scan (p<0.001). In the multivariate analysis of death predictors, significant contributors were the degree of COVID-19 pulmonary lesions (OR 4.84, 95% CI 1.21–20.84, p=0.035) followed by age (OR 1.12, 95% CI 1.04–1.20, p=0.002) and maximum recorded level of glycaemia during hospitalisation (OR 1.01, 95% CI 1.00–1.01, p=0.035), but not gender (p=0.078), SaO2 at admission (p=0.262) or CRP level (p=0.721).Conclusions: Severe COVID-19 pulmonary lesions, older age and a higher alteration of glycemic profile could predict severe outcome.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3815.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -