TY - JOUR T1 - Association between Pulmonary Infections and the Prognosis in Patients with Idiopathic Pulmonary Fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3755 VL - 58 IS - suppl 65 SP - PA3755 AU - Masuda Norestani AU - M. Norestani AU - N. Hoyer AU - Z. Barrella Harboe AU - S.B. Shaker Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3755.abstract N2 - Background: The mechanisms underlying IPF are incompletely understood. Infections may induce alveolar epithelial cell damage and modulate the host response to injury that can contribute to the development of IPF.Aim: To describe the burden of respiratory tract infections in IPF patients and determine their impact on disease course and survival.Methods: Patients with IPF (n=315) recruited in the prospective study Danish PFBIO-cohort were included in the analysis. Data on pulmonary function, microbiology (throat, nasopharynx swaps, sputum, tracheal aspirate, BAL-fluid) and mortality were retrieved. Patients were followed for up to 4 years. Progression was defined as FVC decline > 10% or DLCO decline > 15% during follow-up. A Cox proportional hazards model, adjusted for age, sex, DLCO and FVC at baseline, smoking status and comorbidities was used to evaluate survival and progression free survival.Results: The study included 315 patients, we found 102 positive bacterial samples from the respiratory tract out of a total 1429 samples. The adjusted analysis, survival was better among patients with no positive bacterial samples and no positive S. pneumoniae samples, and the same tendency was observed in progression free survival figure 1.Conclusion: Laboratory confirmed bacterial pulmonary infections are associated with poorer survival and disease progression among patients with IPF.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3755.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -