RT Journal Article
SR Electronic
T1 Association of laboratory markers with oxygen saturation and radiological findings in hospitalized COVID-19 patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3877
DO 10.1183/13993003.congress-2021.PA3877
VO 58
IS suppl 65
A1 Dragan Mijakoski
A1 Zorica Markovska
A1 Iskra Meshkova
A1 Sasho Stoleski
A1 Jordan Minov
A1 Jovanka Karadzinska-Bislimovska
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3877.abstract
AB Aim: of the study was to evaluate the association of COVID-19 symptoms and certain laboratory markers with oxygen saturation (SaO2) and radiological findings in hospitalized COVID-19 patients.Methods: Retrospective cohort study of 117 patients with COVID-19 at the City General Hospital 8th September, Skopje. SaO2 and radiological findings were analyzed as dependent variables. COVID-19 symptoms (e.g., increased temperature, dyspnea, cough, shortness of breath, severe general condition), and laboratory markers were retrospectively obtained from medical records. Each COVID-19 symptom was dichotomously registered (0=absent, 1= present). We analyzed C-reactive protein (CRP), lactate dehydrogenase (LDH), and D-dimmers as laboratory markers. SaO2 was measured by pulse oximeter. Radiological findings were classified (1=normal finding, 2=peripheral opacities, and 3=consolidations). Series of regression models were tested to examine associations of symptoms and laboratory markers to SaO2 and radiological findings, controlling for age, gender, and number of identified co-morbidities.Results: SaO2 was negatively predicted by either LDH (β = -0.664, p < 0.001) and D-dimmers (β = -0.181, p < 0.05) (R2 for the model = 0.549), or shortness of breath (β = -0.201, p < 0.05) and severe general condition (β = -0.345, p < 0.01) (R2 for the model = 0.25). Severe general condition (β = 0.28, p < 0.01) predicted more progressed radiological findings (R2 for the model = 0.175).Conclusion: Certain symptoms and laboratory markers, especially LDH and D-dimmers have to be taken into consideration in hospitalized patients with COVID-19 infection.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3877.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).