RT Journal Article
SR Electronic
T1 Morphological features of non-tuberculous mycobacteriosis in patients operated on for lung tuberculosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3084
DO 10.1183/13993003.congress-2021.PA3084
VO 58
IS suppl 65
A1 Lepeha, Larisa
A1 Aliev, Vilayat
A1 Chernousova, Larisa
A1 Krasnikova, Elena
A1 Makaryants, Natalia
A1 Bagirov, Mamed
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3084.abstract
AB Introduction: In recent years, cases of detection of slow-growing non-tuberculosis mycobacteria in patients operated on for tuberculosis have become more frequent.Objective: Revealing the differences between morphological picture of tuberculosis and non-tuberculous mycobacteriosis in the lung resection material of patients with combined pathology.Methods: A morphological, microbiological and molecular genetic study of the surgical material of 38 patients was carried out. All the patients had a confirmed diagnosis of tuberculosis, and slowly growing non-tuberculosis mycobacterias were found in the surgical material.Results: The spread of non-tuberculosis mycobacteria in patients with pulmonary tuberculosis is accompanied by abundant lymphoid infiltration of the pulmonary parenchyma, the formation of numerous histiocytic-macrophage granulomas without necrosis, which is especially typical of M. avium (22.5%) and M. intracellulare (7.5%). Lymphoid-histiocytic infiltration of the walls of the terminal bronchioles and peribronchial pulmonary parenchyma, as well as single fibrous necrosis are characteristic for M. Kansasii (30%) and M. Xenopi (27.5%).Conclusion: The obtained data are necessary for the differential diagnosis of pulmonary tuberculosis and non-tuberculous mycobacteriosis.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3084.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).