RT Journal Article SR Electronic T1 Late Breaking Abstract - 12-month lung clinical and functional consequences in patients with severe COVID-19 JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3893 DO 10.1183/13993003.congress-2021.PA3893 VO 58 IS suppl 65 A1 Gulnara Abdullaeva A1 Malika Mustafina A1 Segey Avdeev A1 Galina Gordina YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/PA3893.abstract AB Background: The long-term lung functional consequences among patients recovered from the novel coronavirus infection (COVID-19) remain largely unclear.Objectiv: to investigate the influence of Coronavirus disease 2019 (COVID-19) on pulmonary function during 12-month recovery phase observation.Methods: 21 patients (14 M/ 7 F, mean age 62 ± 9 yrs) without concomitant bronchopulmonary pathology were examined within 12 months after COVID-19. The degree of lung damage determined by high-resolution computed tomography (CT) in all patients in acute stage were 50-75% (67%) and ≥75% (33%). Pulmonary function tests (PFT) (spirometry, body plethysmography, gas transfer test), 6-minute walking test (6MWT) and CT were performed.Results: The majority of PFTs parameters were in normal values, but diffusing capacity (DLco) was decreased in 62% of patients. At 12 months after discharge, severe radiological changes (more than 50% lung tissue damage) persisted in 7 (33%) patients and mild (less than 50% lung tissue damage) – in 14 (67%) patients. Statistically significant correlations were shown between 6MWT and DLco (r=0.7, p=0.003).Conclusion: Impaired diffusing capacity was detected in more than half of the severe COVID-19 patients during 12-month recovery phase. The degree of lung function impairment correlates with physical capacity.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3893.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).