TY - JOUR T1 - Comparative predictive assessment of lung health status in young people JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3631 VL - 58 IS - suppl 65 SP - PA3631 AU - Natalya Alexandrovna Mokina AU - Egor Dmitrievich Mokin Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3631.abstract N2 - Actuality: Chronic non-specific lung diseases as part of the continuation of the development of chronic non-specific lung diseases is a global issue of the health care system, with more than 40% of all cases of morbidity, which determines the relevance of early personalized diagnosis for predicting and preventing chronic non-specific lung diseases. The aim is to conduct a comparative predictive assessment of the lung health status in young people.Material and methods: This study involved 293 young people, 11-23 years old, 142 male and 151 female. Differences were identified in anamnestic (smoking factor, acute respiratpry infections frequency per year, diagnosis of chronic non-specific lung diseases), clinical and functional (symptoms, spirometry, electronic auscultation, exhaled carbon monocide and nitrogen monoxide, pulse oximetry) and genetic parameters (alpha-1-antitrypsin and SERPINA-1 serum).Results: Significant differences were established by FEV1%, FVC%, Tiffno index (FEV1/FVC%), according to electronic auscultation data, with a predominance of obstructive murmurs in smokers with and without chronic non-specific lung diseases. Based on the results, we have developed differential criteria for assessing the phenotypes of the COPD risk degree and an algorithm for assessing the prognostic COPD risk degree in young people.Conclusion: Thus, a comparative assessment of the lung health status in young people showed that, already starting from adolescence, it is possible to record the initial functional disorders of the respiratory status, in combination with genetic polymorphisms, which increases the prognostic risk of developing chronic non-specific lung diseases in older age and dictates the need for predicting and prevention within the paradigm of personalized medicine.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3631.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -