PT - JOURNAL ARTICLE AU - Verónica Pulito-Cueto AU - Sara Remuzgo-Martínez AU - Fernanda Genre AU - Belén Atienza-Mateo AU - Victor M. Mora-Cuesta AU - David Iturbe-Fernández AU - Leticia Lera-Gómez AU - Raquel Pérez-Fernández AU - Pilar Alonso-Lecue AU - Javier Rodriguez-Carrio AU - Diana Prieto-Peña AU - Virginia Portilla AU - Ricardo Blanco AU - Alfonso Corrales AU - Jose M. Cifrián AU - Raquel López-Mejías AU - Miguel A. González-Gay TI - Angiogenic T cells in interstitial lung diseases AID - 10.1183/13993003.congress-2021.PA3620 DP - 2021 Sep 05 TA - European Respiratory Journal PG - PA3620 VI - 58 IP - suppl 65 4099 - http://erj.ersjournals.com/content/58/suppl_65/PA3620.short 4100 - http://erj.ersjournals.com/content/58/suppl_65/PA3620.full SO - Eur Respir J2021 Sep 05; 58 AB - Background: Interstitial lung diseases (ILD) lead to an increase in the patient’s morbidity and mortality. According to the etiology, ILD can be divided in disorders with either an unknown or known possible cause such as an underlying connective tissue disease (CTD) [1]. A specific T cell subset termed angiogenic T cells (TAng), that promote endothelial repair and revascularization, has been involved in the pathogenesis of CTD [2]. Nevertheless, little is known about their role in ILD.Objective: To assess the potential role of TAng in ILD.Methods: Peripheral venous blood was collected from 61 patients with ILD (composed of 21 with idiopathic pulmonary fibrosis (IPF) and 40 with CTD-ILD+), 44 CTD-ILD- patients and 20 healthy controls (HC). Quantification of TAng was performed by flow cytometry. TAng were considered as triple-positive for CD3, CD31 and CXCR4.Results: Patients with ILD exhibited a significantly lower TAng frequency than CTD-ILD- patients and HC (mean ± standard deviation: 11.98 ± 4.75 versus 16.24 ± 5.03 and 11.98 ± 4.75 versus 16.50 ± 4.83, respectively, p< 0.001 in both cases). However, no statistically significant difference was observed between CTD-ILD- patients and HC.Conclusion: Our results disclose a decrease of TAng frequency related to the presence of ILD.References: [1] J Clin Med 2020;9(6):1606; [2] Ann Rheum Dis 2015 74(5):921-7. Personal funds, VP-C: PREVAL18/01 (IDIVAL); SR-M: RD16/0012/0009 (ISCIII-ERDF); LL-G: INNVAL20/06 (IDIVAL); RP-F: START PROJECT (FOREUM); RL-M: Miguel Servet type I CP16/00033 (ISCIII-ESF).FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3620.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).