PT  - JOURNAL ARTICLE
AU  - Mark Nagel
AU  - Amanda Bracey
AU  - Alison Ellery
AU  - Jason Suggett
TI  - Cost Effectiveness Comparison of a Dry Powder Inhaler to a Metered Dose Inhaler plus Valved Holding Chamber based on a Functional Respiratory Imaging (FRI) Model
AID  - 10.1183/13993003.congress-2021.OA4281
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - OA4281
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/OA4281.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/OA4281.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: In a previous study [1], FRI was used to predict regional lung deposition from a pMDI+VHC and a commonly prescribed mid-resistance DPI to a representative asthmatic adult respiratory tract.Objective: To compare the relative cost of using a DPI and a pMDI+VHC to deliver fluticasone/salmeterol (FP/SX; Seretide®) in patients for whom medium-dose ICS maintenance therapy is appropriate.Methods: Comparisons were based on FP/SX 125/25µg 2 puffs twice daily for the pMDI option, with yearly cost inputs of £281.4+5.2 for the pMDI + VHC obtained from a relevant source in the United Kingdom (www.rightbreathe.com). The DPI option was based on FP/SX 250/50µg 1 inhalation twice daily, with yearly cost inputs of £420. Drug delivery data was taken from the aforementioned study [1], looking at percentage of label dose delivered to the lungs for pMDI/VHC and DPI systems, using an optimal inhalation technique.Results: The mass (µg) of FP and SX delivered per £ are reported in the table. ProductAPIµg/£/yrSeretide 250 Accuhaler DPIFP43.5SX8.7Seretide 125 Evohaler MDI + VHCFP205.0SX41.0Conclusion: The pMDI/VHC system, using this assessment, was nearly five times as cost effective as the DPI system. Further analysis is required to determine if there would be any quality-adjusted life-year (QALY) effects based on the chosen intervention.[1] Suggett et al. A Comparison, Using Functional Respiratory Imaging (FRI), of Adult Airway Deposition Profiles from a Pressurized Metered Dose Inhaler with Valved Holding Chamber (pMDI/VHC) and Two Dry Powder Inhalers (DPI). Proceedings of RDD Europe 2021FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA4281.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).