TY - JOUR T1 - Lung Function and Lung Mechanics in Post-COVID-19 Patients: What we can Learn? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3167 VL - 58 IS - suppl 65 SP - PA3167 AU - Sergio Ferreira AU - Wendel S Fernandes AU - Ricardo C Alves AU - Patricia B Fialho AU - Maysa A R Brandao-Rangel AU - Claudio R Frison AU - Rodolfo P Vieira Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3167.abstract N2 - This study investigated the possible effects of different severities of COVID-19 on lung function and mechanics. Four patients’ groups were studied: Non-COVID-19 patients (n=21), Mild Post-COVID-19 patients (n=75), Moderate Post-COVID-19 patients (n=33), Severe Post-COVID-19 patients (n=20). Post-COVID-19 were evaluated between 3-15 days after hospital discharge. Lung function was evaluated by spirometry and lung mechanics by impulse oscillometry using MasterScreen (Jaeger, Germany), pre and post 400mcg of salbutamol sulfate. We observed that none post-COVID-19 patients presented impaired lung function (FVC, FEV1, FEV1/FVC, PEF, MEF25%, MEF50%, MEF75%) compared with non-post-COVID-19 patients. Severe post-COVID-19 patients presented increased resistance of the whole respiratory system (R5Hz) compared to non-post-COVID-19 patients (p<0.01), which has not been observed for Mild and Moderate Post-COVID-19. Severe post-COVID-19 presented increased resistance of the whole respiratory system (R5Hz) compared with Mild (p<0.01) and Moderate (p<0.01) post-COVID-19. Severe post-COVID-19 displayed increased resistance of the proximal airways (R20Hz) compared to non-post-COVID-19 (p<0.01), which has not been observed for Mild and Moderate Post-COVID-19. Severe post-COVID-19 presented increased proximal airway resistance (R20Hz) compared with Mild (p<0.01) and Moderate (p<0.01) post-COVID-19. No differences were found for the resistance of small/distal airways (R5Hz-R20Hz). No response was found for bronchodilator for spirometric and impulse oscillometry parameters. Impulse oscillometry is a more sensible method to detect pulmonary alterations in post-COVID-19 patients, without response to bronchodilator.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3167.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -