RT Journal Article
SR Electronic
T1 Parathyroid hormone: a neglected biomarker of exacerbations and hospitalizations in patients with COPD and hypovitaminosis D
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3830
DO 10.1183/13993003.congress-2021.PA3830
VO 58
IS suppl 65
A1 Carlos Antonio Amado Diago
A1 Mayte García-Unzueta
A1 Juan Agüero Calvo
A1 Paula Martín Audera
A1 Sandra Tello Mena
A1 Sheila Izquierdo Cuervo
A1 Guido Andretta Juarez
A1 Joy Selene Osorio Chavez
A1 Marta Cristeto Porras
A1 Laura Gonzalez Ramos
A1 Noelia Borja Vargas
A1 Armando Raul Guerra
A1 Milagros Ruiz De Infante Pérez
A1 Ana Berja
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3830.abstract
AB Background: Hypovitaminosis D has been linked to deterioration in clinical parameters and lung function in COPD. As a response to low levels of vitamin D serum Parathyroid Hormone (iPTH) is increased in some, but not all, patients. The aim of this study was to determine whether COPD patients with elevated PTH levels are at higher risk of COPD exacerbations and hospitalizations.Methods: 166 COPD outpatients were randomly preselected. Clinical and analytical characteristics were assessed at baseline. After excluding patients with other conditions known to disturb calcium metabolism 141 patients were identified. Except one, all patients were prospectively followed for 12 months after obtaining the blood samples. Hypovitaminosis D was considered when serum 25(OH)D <30 ng/mL. Secondary hyperparathyroidism was considered when serum iPTH was higher than normal (50 pg/mL) in patients with hypovitaminosis D. COPD exacerbations and hospital admissions were recorded during the follow-up.Results: Prevalence of hypovitaminosis D in COPD patients was 89.3%, prevalence of secondary hyperparathyroidism associated with hypovitaminosis D was 22,9%. Cox proportional risk analysis showed that patients belonging to the high iPTH-low 25(OH)D group were at a higher risk of moderate COPD exacerbations (HR 1.81 (CI95% 1.043-3.127), p=0.035) and hospital admissions (HR 5.45 (CI95% 2.018-14.720), p=0.002) as compared with those with normal iPTH-low 25(OH)D levels.Conclusions: COPD patients with hypovitaminosis D and elevated iPTH have higher risk of moderate exacerbations and hospitalizations than those with hypovitaminosis D and normal iPTH.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3830.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).