RT Journal Article
SR Electronic
T1 LSC - 2021 - The relationship between the level of C-reactive protein and the general cardiovascular risk in patients with COPD and hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3838
DO 10.1183/13993003.congress-2021.PA3838
VO 58
IS suppl 65
A1 Boiko Olha
A1 Olena Kovalenko
A1 Viktoriia Rodionova
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3838.abstract
AB Background: Arterial hypertension (H) is the most common comorbidity in COPD. An increase in the level of C-reactive protein (CRP) is associated with an increase in cardiovascular risk (CVR) in patients with H. The aim of the study was to identify the relationship between the level of CRP and the total 10-year (tCVR) in stable comorbid patients with COPD and H.Materials and methods: The study included 83 patients. Group I (I) - 42 stable patients with COPD with H stage II, group II (II) - 41 patients with H stage II. The calculation of the tCVR, determination of CRP (enzyme-linked immunosorbent assay), spirometry was carried out.Results: In I the average age (56.0 ± 6.7) years, the tCVR was 5.92[2.58; 10.61]%. Average age in II - (56.9 ± 5.8), total CVR - 5.85 [2.18; 11.48]%. The CRP in I (5.61 [2.55; 10.81] mg /l) was higher than in II (3.67 [1.44; 5.30]), p=0.048. In I the CRP had a negative correlation with the FEV1/FVC (R = -0.50, p=0.001). The CRP in patients of I with FEV1=50% (3.6 [1.55; 10.8] mg/l) did not differ from II, but was significantly lower than in patients with FEV1Conclusions: Increased CRP level in stable comorbid patients with COPD and H is predominantly due to brochoobstruction.While in H, an increase in CBR has a direct relationship with the index of tCVR, in stable patients with comorbidity of COPD and H such a relationship was established only in patients with FEV1 = 50%.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3838.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).