PT - JOURNAL ARTICLE AU - Mohamed Ellayeh AU - Eihab Bedawi AU - Radhika Banka AU - Anand Sundaralingam AU - Vineeth George AU - Nikolaos Kanellakis AU - Robert Hallifax AU - John Wrightson AU - Najib Rahman TI - Thoracoscopic evaluation of the effect of tumour burden on the outcome of pleurodesis in malignant pleural effusion AID - 10.1183/13993003.congress-2021.PA3792 DP - 2021 Sep 05 TA - European Respiratory Journal PG - PA3792 VI - 58 IP - suppl 65 4099 - http://erj.ersjournals.com/content/58/suppl_65/PA3792.short 4100 - http://erj.ersjournals.com/content/58/suppl_65/PA3792.full SO - Eur Respir J2021 Sep 05; 58 AB - Background: It has been postulated that when the intrapleural tumour burden is high, the resultant obliteration of normal mesothelial cell surface of the pleura results in reduction in pleurodesis success rate.Aims: to assess the hypothesis that tumour burden is associated with higher pleurodesis failure, and that tumour type can affect pleurodesis outcomesMethods: Review of recorded video footage of local anaesthetic thoracoscopy (LAT) procedures of 45 patients with proven MPE was conducted by 2 independent assessors blinded to the patient medical records. Abnormalities were assessed according to the presence or absence of; nodules, lymphangitis, inflammation, and adhesions on each of the parietal, visceral and diaphragmatic surfaces. A macroscopic score was developed by adding the number of abnormalities in each pleural surface to produce a total score for tumour burden which was correlated with tumour type and pleurodesis outcomeResults: In both mesothelioma (n=21) and non-mesothelioma (n=24), there were no significant differences between the tumour burden score and the outcome of pleurodesis (p=0.188 and 0.173 respectively). The rate of pleurodesis success was higher in the non-mesothelioma group (n=16; 66.7%) compared to the mesothelioma group (n= 9; 42.9%) with no significant difference between both groups (p=0.11)Conclusion: We found no relationship between tumor burden and pleurodesis outcome. Further prospective evaluation in a larger cohort is underway. Consistent with the reported literature, we found that mesothelioma has a high failure rate of pleurodesis compared to non-mesothelioma patientsFootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3792.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).