PT - JOURNAL ARTICLE AU - Jérémie Pichon AU - Charles Fauvel AU - Anne Roche AU - Athénaïs Boucly AU - Xavier Jaïs AU - Mitja Jevnikar AU - Nathan Ebstein AU - Olivier Sitbon AU - David Montani AU - Marc Humbert AU - Laurent Savale TI - Prognostic value of renal doppler in acute decompensated precapillary pulmonary hypertension AID - 10.1183/13993003.congress-2021.PA1925 DP - 2021 Sep 05 TA - European Respiratory Journal PG - PA1925 VI - 58 IP - suppl 65 4099 - http://erj.ersjournals.com/content/58/suppl_65/PA1925.short 4100 - http://erj.ersjournals.com/content/58/suppl_65/PA1925.full SO - Eur Respir J2021 Sep 05; 58 AB - Although cardiorenal syndrome has been identified as a major prognostic factor in right heart failure (RHF), the prognostic value of renal doppler has never been evaluated in acute decompensated precapillary pulmonary hypertension (PH).The aim of our study was to analyze the prognostic value of the arterial renal resistance index (RRI) and the doppler-derived renal venous stasis index (RVSI) assessed at admission and day-3 in precapillary PH patients admitted in intensive care unit (ICU) for acute RHF. The primary endpoint was a composite endpoint including death, circulatory assistance, urgent transplantation or rehospitalization for acute RHF within 90 days following inclusion.Among the 46 patients analysed (67% female, age 60±15 years), all received intravenous diuretics and 27 (57%) required inotropic and/or vasopressor support. At admission, the median values of RRI and RVSI were respectively 0.75 [IQR, 0.69-0.86] and 0.48 [IQR, 0.27-0.6]. RRI>0.75 was significantly associated with lower eGFR (p=0.023) and lower systemic mean arterial pressure (p=0.015). RVSI>0.48 was associated with lower eGFR (p=0.004), higher central venous pressure (p<0.001) and higher NT-proBNP (p=0.013). A primary endpoint event occurred in 12 patients (24%). In Kaplan–Meier analysis, the event rate was higher in patients with RRI>0.75 at admission (p=0.02) but not in patients with RVSI>0.48. At day-3, a decrease in both RRI and RVSI was associated with better outcomes (p=0.003 and p<0.0001, respectively). No event occurs in patients who improved both RRI and RVSI at Day 3.Arterial and venous renal doppler seem to be relevant tools for prognostic evaluation of acute decompensated precapillary PHFootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1925.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).