RT Journal Article SR Electronic T1 Association between mortality of Idiopathic Pulmonary Fibrosis and air Pollution levels in Madrid JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3761 DO 10.1183/13993003.congress-2021.PA3761 VO 58 IS suppl 65 A1 Pablo Mariscal Aguilar A1 Luis Gómez Carrera A1 Carlos Carpio Segura A1 Ester Zamarrón De Lucas A1 María Hidalgo Sánchez A1 Gema Bonilla Hernán A1 María Isabel Torres Sánchez A1 María Fernández-Velilla Peña A1 Prudencio Díaz-Agero Álvarez A1 Elena Villamañán Bueno A1 Rita Regojo Zapata A1 Concepción Prados Sánchez A1 Rodolfo Álvarez-Sala Walther YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/PA3761.abstract AB Aim: To assess the relationship between air pollution and the mortality of IPF.Methods: The probability of death was analysed from 52 IPF patients diagnosed in our ILD Unit from 2011 to 2019 and it was related to the values of (CO, NO2, PM2.5, PM10, O3 and SO2) in Madrid during that period.Results: Fifty-two patients were reviewed with a mean age of 66±10 years at the time of diagnosis, 11 (21%) of them were women.The average of the pollutants from the three months prior to the date of death of the 18 (34.6%) patients who died was SO2=8,48 ± 0,59 μg/m2, NO2=55,59 ± 2,43 μg/m2, CO=0,39 ± 0,02 mg/m2, O3=41,03 ± 3,79 μg/m2, PM2,5=11,09 ± 0,53 μg/m2, PM10= 21,17 ± 0,94 μg/m2 and the average air in the previous three months to the last clinic visit in 34 (65,6%) patients who are still alive was SO2 =8,26±0,43μg/m2, NO2=53,02±1,76μg/m2, CO=0,27±0,01 mg/m2 O3=46,08±2,76 μg/m2 PM2,5=10.97±0,38 μg/m2 PM10=21,91±0,68 μg/m2.We observed that pollution levels in all patients were associated with the likelihood of dying in one case: OR SO2= 1,19 (0,37-3,82) (p=0,75), OR CO=2,45 (1,39-4,56) (p=0,005), OR NO2 = 1,13 (0,84-1,50) (p=0,39), OR O3 = 0,90 (0,75-1,09) (p=0,28), OR PM2,5 = 1,12 (0,30-4,23) (p=0,85), OR PM10 = 0,78 (0,37-1,66) (p=0,51).Conclusion: Mortality was significantly associated with increased CO exposure, with an OR of 2.45 (95% CI 1.39-4.56) for each increase of 0.1 mg/m2. No association was observed between IPF mortality and all other contaminants studiedFootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3761.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).