PT  - JOURNAL ARTICLE
AU  - Nilsson, Ulf
AU  - Söderberg, Stefan
AU  - Backman, Helena
AU  - Blomberg, Anders
AU  - Lindberg, Anne
TI  - Leptin levels are associated with reduced lung function in men with COPD
AID  - 10.1183/13993003.congress-2021.PA3512
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA3512
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA3512.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA3512.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: The adipokine leptin associates with cardiovascular diseases (CVD), and with disease severity in COPD. Cardiovascular comorbidities are common in COPD, but it is unclear how leptin is distributed in population-based samples of individuals with COPD.Aim: To compare the distribution of leptin concentrations in subjects with COPD and normal lung function (NLF), and by COPD severity.Methods: In 2002-04, subjects with FEV1/VC ≤0.70 (COPD, n=993) and age and sex-matched referents without COPD were identified from population-based cohorts. In 2005, 593 subjects with COPD (42% women) and 752 referents with NLF (48% women) were examined with structured interview, post-bronchodilatation spirometry and blood sampling. Serum leptin concentrations were determined using ELISA. Statistical analyses were stratified for sex.Results: Median leptin concentrations did not differ between COPD and NLF. In men with COPD, leptin concentrations were inversely associated with FEV1%predicted (pp) (r=-0.233, p<0.001), and in multiple linear regression models (β [95% CI]), leptin (logarithmized) associated inversely with both FEV1 (-0.146 [-0.246– -0.045] p=0.005) and FEV1pp (-0.807 [-1.183– -0.431] p<0.001) after adjustments for age, BMI and smoking. Leptin did not associate with any lung function parameter in women with COPD, nor in men or women with NLF.Conclusion: In this population-based sample, reduced lung function was associated with increased serum leptin concentrations among men, but not women, with COPD. Further studies are needed to evaluate a possible sex-dependent association with regard to leptin and CVD in COPD.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3512.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).