RT Journal Article
SR Electronic
T1 Asthma control, exacerbations, airway obstruction and reversibility in children before and after SARS-CoV-2 pandemic onset
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3924
DO 10.1183/13993003.congress-2021.PA3924
VO 58
IS suppl 65
A1 Nicole Beydon
A1 Florence Coquelin
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3924.abstract
AB Background: COVID19 did not demonstrate more frequent or severe disease in asthmatic children, but few is known on its effect on symptoms and lung function.Objectives: To compare asthma symptoms and lung function during first and two last quarters of 2019 with these of 2020.Methods: Retrospective study in asthmatic children seen for lung function assessment. Proportions of children and functional indexes were compared using Chi-2 and t-Student tests, respectively.Results: Distribution of 3419 files across the first, and two last quarters of 2019 and 2020 was 672, 542, 657, and 476, 495 and 577, respectively. Asthma control and exacerbation were quoted in 3166 (92.6%) and 3062 (89.6%) files. Asthma control was similar during the first and third quarters of 2019 and 2020 (P=0.37 and P=0.84, respectively). Total asthma control was more frequently achieved in the last 2020 quarter compared to that of 2019 (75.5% vs 70.3%, P=0.042). Frequency of children with at least one exacerbation in the previous 3 months was higher during first 2020 quarter (59.7% vs 52.4%; P = 0.022) but lower during the two last 2020 quarters (33.3% vs 47.6%, and 44.7% vs 59%, both P<0.0001). Baseline and post-bronchodilator spirometry (2487 files) showed higher FEV1/FVC Z-scores in the last two quarters of 2020 compared to 2019 (-0.62 and -0.53 vs -0.82 and -0.72, respectively; both P<0.03) with less FEV1 reversibility (4.4 and 4.2 vs 5.1 and 5%baseline, respectively; both P<0.04).Conclusion: Asthma control improved during the first winter after the pandemic onset in line with less airway obstruction or reversibility while exacerbations were more frequent just before the recognition of the epidemic.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3924.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).