RT Journal Article
SR Electronic
T1 Impact of Aspergillus fumigatus infection on lung function in children with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3377
DO 10.1183/13993003.congress-2021.PA3377
VO 58
IS suppl 65
A1 Ludmila Balanetchi
A1 Rodica Selevestru
A1 Mariana Cotorobai
A1 Diana Rotaru-Cojocari
A1 Cristina Tomacinschi
A1 Natalia Barbova
A1 Eva Gudumac
A1 Svetlana Sciuca
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3377.abstract
AB Aim: Evaluation of the impact of Aspergillus fumigatus infection on lung function in children with cystic fibrosis (CF).Methods: The study included 32 pediatric patients with CF, which was confirmed by the sweat test and molecular diagnosis for CFTR mutations. Aspergillus fumigatus infection was confirmed by tests to assess the titer of antibodies (Ac) specific to IgA, IgM, IgG, serum IgE-Aspergillus fumigatus concentration, galactomannan level. Lung function was assessed by spirometry with FVC, FEV1 ("Autospiro Pal", Japan).Results: The basic group included 15 CF patients (68,2%:95CI 45,1-86,1) with Aspergillus fumigatus infection and the control group-17 CF patients (31,8%:95CI 13,9-54,9 ). The average age of the children in the basic group was 12,2±1,06 years (7,1-18 years) and the average age of the children in the control group was 9,9±1,43 years (6-17 years); p> 0,05. The mean values of the Ac anti-Aspergillus fumigatus titer in this group were 1:415±52,9 (maximum titer 1:640, minimum 1:320, median 1:320, Mo 1:320).In CF patients with pulmonary aspergillosis FVC had lower values – 53,2±5,9% (maximum value 88%, minimum 26%, median 49%, Mo 26%) compared to children in the control group - 61,3±13,4% (maximum 98%, minimum 31%, median 59,5%, Mo 31%), statistical T=0,69, p <0,05. The obstructive disorders assessed by FEV1 in the patients in the study group were more expressed – 50,4±6,9% (maximum 88%, minimum 20%, median 44%, Mo 31%) compared to non-Aspergillus CF children - 61±14,1% (maximum 100%, minimum 31%, median 55%, Mo 31%), statistical T=0,81, p <0,05.Conclusion: Aspergillus fumigatus infection in children with CF has a severe impact on restrictive and obstructive respiratory function.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3377.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).