TY - JOUR T1 - The effect of antioxidants on oxidative metabolism in smokers JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA721 VL - 58 IS - suppl 65 SP - PA721 AU - Svetlana K. Soodaeva AU - I Klimanov AU - E Zaprudnova AU - L Churkina AU - T Li AU - N Popova AU - N Kubysheva AU - V Novoselov AU - L Nikitina Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA721.abstract N2 - Aim of the study: to study the effect of taking antioxidant vitamins C and E on the oxidant-antioxidant system in the exhaled air condensate (EBC) of smokers and nonsmokers.Materials and methods: The study involved 40 people: 20 practically healthy people (20 - 40 years old) and 20 smokers of the same age. For three weeks, everyone took vitamins C (100 mg / day) and E (100 mg / day). All subjects were collected EBC before and after the experiment. NO metabolites - the total concentration of nitrates and nitrites, and the activity of catalase - were determined in the EBC.Results: Initial measurements in EBC showed that healthy nonsmokers had higher levels of NO metabolites than smokers (p <0.05). After a course of antioxidant intake, the concentration of NO metabolites significantly decreased in both groups, and the differences in the groups of smokers and non-smokers became insignificant (p> 0.05). Also, after taking vitamins, a decrease in catalase activity was noted in both groups, and the difference in indicators between the groups also became insignificant (p = 0.2). Catalase activity in nonsmokers decreases 1.6 times (p <0.008), and in smokers, 1.8 times (p <0.007).Conclusion: Thus, taking antioxidants C and E for three weeks leads to a decrease in the level of both oxidants and antioxidants, helping to restore the balance of oxidative metabolism. This is especially important for the group of smokers, since smoking disrupts the balance in the oxidant-antioxidant system, as a result of which negative processes of oxidative stress are triggered.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA721.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -