TY - JOUR T1 - Does the type of bacterial colonization in lower airways affect the lung function in patients with Primary Ciliary Dyskinesia (PCD)? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA573 VL - 58 IS - suppl 65 SP - PA573 AU - Vanessa Fein AU - Anne Schlegtendal AU - Christoph Maier AU - Cordula Koerner-Rettberg AU - Folke Brinkmann Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA573.abstract N2 - Backgound: The pattern of bacterial colonization in the lower airways of patients with PCD changes over time. Studies show that younger patients are predominantly colonized with H. influenzae and M. catarrhalis whereas adults show P. aeruginosa significantly more often. The number of different pathogens increases with the patients’ age. P. aeruginosa is associated with a lower FEV1 and a young age of diagnosis reduces the risk of colonization with this pathogen. Studies evaluating the long-time effect of the colonization pattern on lung function in PCD are rare.Aims: The aim of our study is to evaluate whether a chronic or intermittent bacterial colonization in PCD with different pathogens leads to a decrease in lung function and more frequent exacerbations.Methods: We performed a retrospective analysis of microbiological results, clinical data and lung function parameters from 03/2010 - 12/2020.Results: We included 44 patients (22 female, 22 male) who regularly attended the Paediatric Pneumology Outpatient Department. Medium follow up period was 7.7 years and the medium number of visits 38. Medium age of patients at appointments was 13.6 years.The most frequent pathogen found in the 1398 available microbiological samples was H. influenzae (262x, 18.74%), followed by S. aureus (148x, 10.59%), M. catarrhalis (65x, 4.65%) and P. aeruginosa (51x, 3.65%).In the following analysis, we evaluate the lung function parameters and correlate them with colonization patterns. A preliminary evaluation suggests that the impact of bacterial colonization on the course of lung function in patients with PCD is more individual than in CF.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA573.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -