PT  - JOURNAL ARTICLE
AU  - Jeisson Osorio Trujillo
AU  - Olga Tura-Ceide
AU  - Javier Pavia
AU  - Ivan Vollmer
AU  - Isabel Blanco
AU  - Valerie Smolders
AU  - Aida Ninerola
AU  - Pilar Paredes
AU  - Jesús Ruiz-Cabello
AU  - Manel Castellà
AU  - Yolanda Torralba
AU  - Laura Sebastián
AU  - Lucilla Piccari
AU  - Víctor Peinado
AU  - Daniel Aguilar
AU  - Joan Albert Barberà
TI  - 18-FDG uptake on PET-CT and metabolism in pulmonary arterial hypertension
AID  - 10.1183/13993003.congress-2021.PA588
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA588
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA588.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA588.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: Proliferative changes in pulmonary hypertension can contribute to the development of idiopathic pulmonary arterial hypertension (iPAH). Energy needed to support cell proliferation may rely on aerobic glycolysis (Warburg effect). Image assessment of cell proliferation in PAH with FDG PET/CT (18F fluorodeoxyglucose positron emission tomography/computed tomography) have shown increased cellular metabolism in right ventricle (RV), while the results in pulmonary artery (PA) and pulmonary parenchyma (PP) are contradictory. In this study we evaluated the relationship between cellular metabolism in PA, RV and PP assessed with FDG PET/CT and the metabolic profile in plasma in patients with iPAH.Methods: We evaluated 12 patients with iPAH who underwent PET/CT scanning and 18F-FDG uptake (SUV) in predefined regions of interest were correlated with clinical and hemodynamic parameters, as well as with levels of plasma metabolites. as well as with levels of plasma metabolites assessed by quantitative targeted metabolomic studies using liquid chromatography (LC) coupled to mass spectrometry.Results: The RV SUV correlated with pro-BNP, 6MWD and cardiac index. Patients with iPAH had increased levels of isoleucine, 15-Hydroxyeicosatetraenoic acid (15-HETE), Glutamic acid and diacylglycerol 36:3 (DG 36:1) among other metabolites that were correlated with FDG uptake in FDG PET/CT (Table 1)Conclusions: In iPAH, the intensity of FDG uptake in pulmonary arteries, right ventricle, and lung parenchyma is associated with systemic parameters that reflect increased cell metabolism. Overall, our findings support the notion of increased cell proliferation in iPAH.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA588.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).