RT Journal Article SR Electronic T1 Association of symptom subtypes and obstructive sleep apnoea-specific hypoxic burden with cardiovascular morbidity and all-cause mortality JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2491 DO 10.1183/13993003.congress-2021.PA2491 VO 58 IS suppl 65 A1 Wojciech Trzepizur A1 Margaux Blanchard A1 Timothée Ganem A1 Frédéric Balusson A1 Mathieu Feuilloy A1 Jean-Marc Girault A1 Nicole Meslier A1 Emmanuel Oger A1 Audrey Paris A1 Thierry Pigeanne A1 Jean-Louis Racineux A1 Chloé Gervès-Pinquié A1 Frédéric Gagnadoux YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/PA2491.abstract AB Background: Data from population-based cohorts suggest that symptom subtypes and obstructive sleep apnea (OSA) specific hypoxic burden (HB) could help to better identify patients with OSA at high cardiovascular (CV) risk.Aim: We aimed to evaluate whether OSA symptoms subtypes and HB derived from sleep recordings were associated with increased CV risk in clinical setting.Methods: Clinical data from a large multicenter cohort were linked to health administrative data to identify new-onset of CV events and death in patients with OSA and no overt CV disease. Latent class analysis was used to identify subtypes based on 8 clinically relevant variables. HB was defined as the total area under the respiratory event-related desaturation curve. Cox proportional hazards models were used to evaluate the association of symptom subtypes and HB with a composite outcome of incident CV events or death from any cause.Results: Four symptom subtypes were identified (minimally symptomatic [22.0%], disturbed sleep [17.5%], excessively sleepy [49.8%], and moderately sleepy [10.6%]), similar to prior studies. After a median follow-up of 78 months, 592 (11.05%) of 5358 patients experienced our composite outcome. In a fully adjusted model, increasing age and HB, male gender, the presence of diabetes, hypertension and COPD were significant predictors of the composite outcome. AHI and symptom subtypes were not associated with CV risk after adjustments.Conclusion: In clinical setting, patients with OSA who demonstrate elevated OSA specific HB are at higher risk of CV event and all cause mortality. Symptom subtypes have no predictive value after adjustment for confounders.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2491.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).