RT Journal Article
SR Electronic
T1 Clinical utility of impulse oscillometry (IOS) versus multiple breath washout (MBW) in school-age asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3922
DO 10.1183/13993003.congress-2021.PA3922
VO 58
IS suppl 65
A1 Sanna Kjellberg
A1 Anna-Carin Olin
A1 Paul Robinson
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3922.abstract
AB Introduction: The relationship between MBW and IOS derived indices of small airway dysfunction and its correlation with clinical information have been rarely directly compared in school-age asthma.Aim: To compare the association between IOS and MBW derived indices of small airway dysfunction and correlation with clinical asthma outcomes.Methods: 57 (17 females) asthmatics aged 8-18 yrs from a secondary care center performed spirometry, exhaled nitric oxide (FeNO), sulphur hexafluoride (SF6) MBW, IOS and dry air hyperventilation challenge (DAHc). Predictive values for SF6 MBW (n=69, 8-18 yrs) and IOS (n=153, 6-18 yrs) were derived from two healthy control cohorts. Clinical asthma outcomes included: ACT-score, burden of asthma medication, airway inflammation (FeNO), and airway response to bronchodilation (BD) and DAHc.Results: Abnormality occurred in 18% for FEV1, 55% for R5-R20, 11% for LCI, 54% for Scond and 23% for Sacin. Scond was abnormal in 74% with abnormal R5-R20. Of MBW indices, Scond showed the strongest and most frequent significant correlations to clinical outcomes: with FEV1 BD response (ρ 0.67, p<0.001), FeNO (ρ 0.39, p<0.01), burden of asthma medication (ρ 0.41, p<0.01) and airway response after DAHc (ρ 0.43, p<0.001). R5-R20 demonstrated weak correlations with response to BD (ρ 0.31, p<0.05) and with FeNO (ρ -0.34, p<0.05).Conclusions: R5-R20 and Scond were abnormal in the majority of school-aged children with asthma in a secondary care center. Abnormal IOS and MBW were complimentary with some discordance evident. Important clinical features of asthma, like response to BD and DAHc, correlated more strongly with MBW derived Scond than IOS derived R5-R20.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3922.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).