RT Journal Article
SR Electronic
T1 Effect of pregnancy on asthma control: a cohort study in rural Sri Lanka
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA4216
DO 10.1183/13993003.congress-2021.OA4216
VO 58
IS suppl 65
A1 Shashanka Indeevara Rajapakse Rajapakse Mudiyanselage
A1 Nuwan Darshana Wickramasinghe
A1 Thilini Chanchala Agampodi
A1 Gayani Amarasinghe
A1 Ayesh Hettiarachchi
A1 Imasha Upulini Jayasinghe
A1 Iresha Koralegedara
A1 Janith Warnasekara
A1 Suneth Buddhika Agampodi
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/OA4216.abstract
AB Introduction: Effect of poor control of asthma-the most common chronic disease complicating pregnancy-in rural populations is not adequately studied.Objective: To assess the symptom profile, progression and outcomes of asthma complicating pregnancy.Methods: A community-based cohort study was conducted among all pregnant women registered in the maternal care programme in July-September 2019 in Anuradhapura, Sri Lanka. Full clinical assessment was done in 1st(T1) and 2nd(T2) trimesters and pregnancy outcome data were obtained from labour rooms.Results: Of the 3374 pregnant women assessed, the prevalence of self-reported physician-diagnosed asthma was 6.6%(n=223). The prevalence of wheeze among asthmatics reduced (p<0.01) from pre-pregnancy (last 3 months before pregnancy) (67.0%;95%CI 60.3-73.1) to T1 (46.7%;95%CI 39.6-53.2) and T2 (47.7%;95%CI 37.9-57.5). The frequency of wheeze increased in 53(25.4%) and 22(23.4%) asthma patients and new-onset wheeze was reported by 6(8.1%) and 12(16.2%) in T1 and T2. Pregnant women who sought medical care for asthma at the private sector had a lower likelihood of developing new-onset wheeze in T1(OR=0.51; 95%CI 0.44-0.59; p=0.03). The prevalence of non-cardiac dyspnoea in pre-pregnancy among asthmatics (20.4%), increased(p=0.11) in T1 (23.3%) and T2 (28.3%;95%CI 20.0-37.9).Incidence of miscarriage, preterm delivery and low birth weight (LBW) among asthmatics was 9.5% (95%CI 6.0-14.1), 11.1% (95%CI 7.0-16.5) and 16.0% (95%CI 11.1-22.1). Wheezing in T2 significantly associated with LBW (OR=3.2, 95%CI 1.04-9.6; p=0.04).Conclusion: Significant changes in asthma symptom control during pregnancy and adverse pregnancy outcomes were observed in this pregnancy cohort in rural Sri Lanka.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA4216.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).