TY - JOUR T1 - Phenotypes of persistent asthma in adolescents revealed different patterns in longitudinal asthma-related outcomes JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.OA2566 VL - 58 IS - suppl 65 SP - OA2566 AU - Rita Amaral AU - Cristina Jácome AU - Rute Almeida AU - Ana Pereira AU - Magna Alves-Correia AU - Sandra Mendes AU - José Cidrais Rodrigues AU - Joana Carvalho AU - Luís Araújo AU - Alberto Costa AU - Armandina Silva AU - M Fernanda Teixeira AU - Manuel Ferreira-Magalhães AU - Rodrigo Rodrigues-Alves AU - Ana Sofia Moreira AU - Ricardo Fernandes AU - Rosário Ferreira AU - Paula Leiria-Pinto AU - Nuno Neuparth AU - Diana Bordalo AU - Ana Todo-Bom AU - M José Cálix AU - Tania Ferreira AU - Joana Gomes AU - Carmen Vidal AU - Ana Mendes AU - M Joã Vasconcelos AU - Pedro Morais Silva AU - José Ferraz AU - Ana Morête AU - Cláudia S Pinto AU - Natacha Santos AU - Cláudia Chaves Loureiro AU - Ana Arrobas AU - Maria Luís Marques AU - Carlos Lozoya AU - Cristina Lopes AU - Francisca Cardia AU - Carla Chaves Loureiro AU - Raquel Câmara AU - Inês Vieira AU - Sofia Da Silva AU - Eurico Silva AU - Natalina Rodrigues AU - João A. Fonseca Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/OA2566.abstract N2 - We aimed to identify persistent asthma phenotypes among adolescents and to evaluate, longitudinally, their asthma-related outcomes.A secondary analysis was performed on the prospective, observational and multicenter INSPIRERS studies, and 162 adolescents (13–17 years; 51% male) were analysed. Latent class analysis was applied to 10 variables easily collected in baseline medical visits, both at primary and secondary care, comprehending demographic, environmental, and clinical domains. Longitudinal changes in clinical variables were assessed at a 4-month telephone visit (n=128).A three-class model was selected as the best solution. Adolescents in class 1 (n=87; 68%) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits/month and exacerbations/month, both at baseline and follow-up. Class 2 (n=32; 25%) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms (both measured by Control of Allergic Rhinitis and Asthma Test, CARAT) at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p<0.001). Class 3 (n=43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in the number of exacerbations/month (p=0.015).We identified three distinct phenotypes of persistent asthma in adolescents that differed in longitudinal patterns of asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2566.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -