RT Journal Article SR Electronic T1 Diagnostic yield and complications of ultrasound-guided transthoracic biopsy in 143 Algerian patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3545 DO 10.1183/13993003.congress-2021.PA3545 VO 58 IS suppl 65 A1 Selmani, Mohamed Redha A1 Chiboub, Bouthayna A1 Djari, Ibtissem A1 Direch, Rania A1 Djebbar, Abdelmadjid YR 2021 UL https://publications.ersnet.org//content/58/suppl_65/PA3545.abstract AB Introduction: Traditionally, biopsies of peripheral pulmonary lesions are the prerogative of radiologist and are often guided by CT scans. Henceforth, with the increased frequency of lung nodules, the pulmonologist is called upon to play a role in their diagnosis, notably by performing ultrasound-guided biopsies.Objectives: Determining diagnostic yield and complication rates of ultrasound-guided transthoracic biopsies (UGTB) performed by pulmonologist and identifying factors impacting yield and complications.Methods: We conducted a prospective monocentric study including 149 UGTB in 143 patients over the period from March 2016 to July 2019.Results: Biopsies were completed in 143 patients (107 lung lesions, 29 pleuro-parietal lesions, 7 mediastinal lesions), and six patients underwent a second biopsy of the same lesion. The overall yield of UGTB was 77.2%. Sensitivity and efficacy for malignant diagnosis was 74% and 76% respectively. The yield was higher when the operator is more experienced with up to 120 procedures (p = 0.004). 27 complications occures (12 hemoptysis, 9 pneumotoraces, 6 vagal reactions). A lesion size < 30mm was a risk factor of hemoptysis (RR = 3.42; 95% CI 1.14-0.27 p = 0.048). The procedure was well tolerated with a pain reported by 36.2% of patients and an average procedure time of 15.7 minutes.Conclusion: UGTB of peripheral thoracic lesions performed by pulmonologists is a reliable technique providing an acceptable diagnostic yield with few complications. An inexperienced operator is a factor of a low diagnostic yield and a lesion size < 3cm is a risk factor for hemoptysis.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3545.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).