PT  - JOURNAL ARTICLE
AU  - Kiryukhina, Larisa
AU  - Dyakova, Marina
AU  - Serebryanaya, Nataliia
AU  - Esmedlyaeva, Dilyara
AU  - Yablonskii, Piotr
TI  - Adenosine-regulated mechanisms in the pathogenesis of ventilation disorders in patients with pulmonary tuberculosis
AID  - 10.1183/13993003.congress-2021.PA3611
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA3611
VI  - 58
IP  - suppl 65
4099  - https://publications.ersnet.org//content/58/suppl_65/PA3611.short
4100  - https://publications.ersnet.org//content/58/suppl_65/PA3611.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Disclosure of the purinergic system involvement in the ventilation disorders (VD) pathogenesis can provide additional information about the pathophysiological mechanisms leading to the VD development in pulmonary tuberculosis (PT) patients.The aim: to study the relationship of adenosine metabolism parameters with ventilation and gas exchange disorders in PT patients.Methods: PT patients without VD (n=23, 1 gr), obstructive (n=26, 2 gr) and mixed (n=11, 3gr) types of VD were studied adenosine deaminase activity (ADA-1, 2) in serum (s), in mononuclear cells (mn), in neutrophils (nph); 5'-nucleotidase (5'-NT) in s; CD26 (dipeptidyl peptidase-4, DPP-4) in s, mn.Results: Patients of all groups showed an increase in ADA-2s (Me>12.0 U/l), 5'-NTs (>0.75 ng/ml) and a decrease in CD26 (DPP-4) mn (<3.8 ng/ml; p<0.05 for all). Decrease in ADA-1s (<2.3 U/l) - in 1 gr and 2 gr, ADA-1mn (1.03 U/106 cells) - in 1 gr, ADA-1nph (<1.2 U/106 cells) - in 2 and 3 gr (p<0.05 of all). The activity of ADA-2s in patients of the 3rd group was higher (19.0 U/l) than in 1 (14.8 U/l) and 2 (12.0 U/l; p<0.05). In 1 and 3gr. VD was associated with ADA-2s and ADA-1nph, whereas in 2 gr – with 5'-NT and CD26 (DPP-4).Conclusion: Purinergic regulation is involved in the regulation of inflammatory and compensatory processes in pulmonary tuberculosis patients. It is associated with the clinical course of the disease, including impaired ventilation efficiency. The most severe respiratory disorders observed in the group of PT patients with mixed type of VD were associated with the most pronounced changes in the nucleotidase enzymes activity, in particular ecto-ADA-2 and CD26 (DPP-4).FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3611.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).