RT Journal Article
SR Electronic
T1 Does a supplementation in branch amino acid improve pulmonary rehabilitation effect in COPD?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3912
DO 10.1183/13993003.congress-2021.PA3912
VO 58
IS suppl 65
A1 Jean-Claude Meurice
A1 Fabrice Caron
A1 Pierre Ingrand
A1 Quentin Bretonneau
A1 Olvier Dupuy
A1 Claire De Bisschop
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3912.abstract
AB Background: Chronic obstructive lung disease (COPD) affects many organs or functions that play an important role in disease progression. Muscle wasting is frequent and associated with low branched-chain amino acids (BCAA). We hypothesized that BCAA supplementation could potentiate the effect of pulmonary rehabilitation program (PRP) and improve exercise capacity by inducing muscular change.Methods: Sixty COPD patients (GOLD 2-3) were involved in an ambulatory 4-week PRP, with BCAA oral daily supplementation (4.3g/daily dose: 25.83% valine, 27.05% isoleucin and 47.12% leucine) or a placebo in a double-blind design. Cardiopulmonary exercise test (Médisoft, Exp’air) including a measurement of quadriceps oxygenation (Oxymon Mk III, Artinis), 6 min walk test, quadriceps muscle strength (Koch bank, Salter dynamometer), lung function, body composition (BioparthΩm, Z Metrix®), dyspnea (mMRC scale) and quality of life (VQ11) were assessed before and after PRPResults: 54 patients (64,9 ± 8,3 years) completed the protocol. In both groups, maximal exercise capacity, functional and muscle performances were increased after 4 weeks PRP (p<0.01), as well as quality of life and dyspnea. However, changes were not more important in the BCAA supplemented group. Changes in quadriceps oxygenation in response to exercise were not modified after PRP, however in BCAA group, p values ≤ 0.07 were obtained at maximal exercise for oxygenated and deoxygenated haemoglobin muscle concentration.Conclusion: This study demonstrated that a 4-week PRP provides a large panel of improvements in COPD patients but that BCAA supplementation does not give more benefit that pulmonary rehabilitation alone.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3912.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).