PT  - JOURNAL ARTICLE
AU  - Chinthaka Samaranayake
AU  - Yingmei Luo
AU  - Karina Siewers
AU  - Christopher Warren
AU  - Stuart Craig
AU  - Carl Harries
AU  - Laura Price
AU  - Aleksander Kempny
AU  - Michael Gatzoulis
AU  - Konstantinos Dimopoulos
AU  - Nicholas Hopkinson
AU  - S John Wort
AU  - James Hull
AU  - Colm Mccabe
TI  - Impact of cyanosis on ventilatory kinetics during stairclimbing in pulmonary arterial hypertension
AID  - 10.1183/13993003.congress-2021.PA3604
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA3604
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA3604.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA3604.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: Breathlessness has significant impact on quality-of-life in patients with pulmonary arterial hypertension (PAH) yet few data assess ventilatory responses during day to day activities. In Eisenmenger syndrome (EIS), the additional impact of cyanosis on symptom profiles is even less well described.Method: Fifteen adult patients with idiopathic PAH (IPAH), six with EIS and fifteen age, sex and BMI-matched controls underwent assessment. Participants completed spirometry and four self-paced stair flights wearing portable CPET equipment. BORG dyspnoea scores were collected at rest and completion.Results: Both IPAH and EIS groups had amplified ventilatory responses. Minute ventilation at stair-climb completion was 44±12, 37±15 and 27±9L/min in EIS, IPAH and Controls respectively (p = 0.01). Peak Tv, RR, Tv:FVC ratio, VE/VCO2 slope and ascent time were higher in EIS and IPAH despite similar spirometry and O2 uptake. EIS patients showed immediate decline in end-tidal CO2 and O2 saturations at stair-climb onset. Peak BORG score correlated with stair-climb time (R=0.73, p=0.002), peak end-tidal CO2 (R=-0.73, p=0.001), peak VE (R=0.53, p=0.008), peak RR (R=0.42, p=0.011) and VE/VCO2 (R=0.54, p=0.001) but not with resting or exercise O2 saturations.Conclusion: Increased ventilatory response to stairclimbing in EIS and IPAH drives higher dyspnoea perception relevant to exercise training and recovery times. FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3604.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).