RT Journal Article
SR Electronic
T1 Late Breaking Abstract - Value of the interleukin profile can be an objective standart for control  the tactics of managing patients with bronchiolitis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA1660
DO 10.1183/13993003.congress-2021.OA1660
VO 58
IS suppl 65
A1 Berezhanskiy, Pavel
A1 Andjel, Andrey
A1 Malachov, Aleksandr
A1 Elagina, Valeria
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/OA1660.abstract
AB Introduction: Bronchiolitis is one of the most common lower respiratory tract infections that affects infants worldwide. In Europe, the estimated annual hospitalization rate for bronchiolitis in 2015 was 46.1 per 1,000 infants. Between 2005 and 2015, these figures grew by an average of 1.7% per year. Despite the high prevalence of bronchiolitis, it is a clinical diagnosis without a single international definition. Indicators of the interleukin profile can be an objective criterion for monitoring the management tactics of patients with bronchiolitis.Materials and methods. The survey included 24 children with a clinically established diagnosis of bronchiolitis at the age from 1 to 7 months. All the patients in the acute stage of the disease were tested for the concentration of interleukins 6, 4 and 18 in blood.Results: Children with grade 2 respiratory distress index, the average IL 6 is 4.2 pg / ml, IL 4 - 0.36 pg / ml, IL 18 - 1737.27 pg / ml, with with grade 1 respiratory distress index is average IL 6 - 10.07 pg / ml, IL 4 - 1.3 pg / ml, IL 18 - 1147.59 pg / ml, without respiratory failure IL 6 - 25.59 pg / ml, IL 4 - 2.39 pg / ml, IL 18 - 612.85 pg / ml. A positive correlation was found between IL18 and the degree of respiratory distress p + 0.86.In patients with a diagnosis of bronchiolitis, depending on the severity of respiratory failure, pronounced changes in the cytokine profile: an increase in the concentration of Il-18 and a decrease in Il-4. These changes are an important objective label for choosing the tactics of managing these patients and predicting a possible deterioration of the degree of respiratory failure.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA1660.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).