PT  - JOURNAL ARTICLE
AU  - Berezhanskiy, Pavel
AU  - Andjel, Andrey
AU  - Malachov, Aleksandr
AU  - Elagina, Valeria
TI  - Late Breaking Abstract - Value of the interleukin profile can be an objective standart for control  the tactics of managing patients with bronchiolitis
AID  - 10.1183/13993003.congress-2021.OA1660
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - OA1660
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/OA1660.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/OA1660.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Introduction: Bronchiolitis is one of the most common lower respiratory tract infections that affects infants worldwide. In Europe, the estimated annual hospitalization rate for bronchiolitis in 2015 was 46.1 per 1,000 infants. Between 2005 and 2015, these figures grew by an average of 1.7% per year. Despite the high prevalence of bronchiolitis, it is a clinical diagnosis without a single international definition. Indicators of the interleukin profile can be an objective criterion for monitoring the management tactics of patients with bronchiolitis.Materials and methods. The survey included 24 children with a clinically established diagnosis of bronchiolitis at the age from 1 to 7 months. All the patients in the acute stage of the disease were tested for the concentration of interleukins 6, 4 and 18 in blood.Results: Children with grade 2 respiratory distress index, the average IL 6 is 4.2 pg / ml, IL 4 - 0.36 pg / ml, IL 18 - 1737.27 pg / ml, with with grade 1 respiratory distress index is average IL 6 - 10.07 pg / ml, IL 4 - 1.3 pg / ml, IL 18 - 1147.59 pg / ml, without respiratory failure IL 6 - 25.59 pg / ml, IL 4 - 2.39 pg / ml, IL 18 - 612.85 pg / ml. A positive correlation was found between IL18 and the degree of respiratory distress p + 0.86.In patients with a diagnosis of bronchiolitis, depending on the severity of respiratory failure, pronounced changes in the cytokine profile: an increase in the concentration of Il-18 and a decrease in Il-4. These changes are an important objective label for choosing the tactics of managing these patients and predicting a possible deterioration of the degree of respiratory failure.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA1660.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).