RT Journal Article
SR Electronic
T1 Hypovitaminosis D and severity of COVID19 respiratory infection in a respiratory intensive care unit (RICU) in Apulia southern Italian region
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3680
DO 10.1183/13993003.congress-2021.PA3680
VO 58
IS suppl 65
A1 Paola Pierucci
A1 Vitaliano Quaranta
A1 Maria Grazia Tummolo
A1 Andrea Portacci
A1 Valentina Di Lecce
A1 Alessandro Palumbo
A1 Pier Luigi Intiglietta
A1 Giovanna Elisiana Carpagnano
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3680.abstract
AB Background: The association between severe hypovitaminosis D (<10ng/ml) and the illness course and deaths related to respiratory failure Coronavirus disease 19 (COVID-19) infection has been already described in the literature. The sun exposure is known to be responsible to increase Vit D circulating level.Aims: To compare the severity of COVID-19 disease and death’s rate with Vit D levels among all patients admitted in a RICU in Bari during the first and second wave of infection before and after sun exposure during summer.Methods: Retrospective, observational single centre study of a total of 83 patients admitted to the COVID RICU in Bari between 1.03.2020-30.04.2020 and 1.09.2020-15.11.2020. Patients with moderate to severe Vitamin D deficiency (<20ng/dl) (Group 1; n = 30) were compared with those with Vitamin D> = 20ng/dl (Group 2; n = 83)Results: A Kaplan Meyer survival curve showed that patients in group1 had significantly reduced survival (Log Rank Mantel Cox 6,836; p = 0.009) compared to group 2. Univariate Cox analysis confirmed that Vitamin D values <20 are a risk factor for mortality (HR 6.370); P = 0.022). Multivariate model of COX Vitamin D values <20 increased the predictive capacity with HR of 30.129 (p = 0.008) compared to the HR of 6.370 of the univariate analysis.Conclusions: In this study, in comparison to previous findings, patients with moderate to severe Vitamin D deficiency (<20ng/dl) have been found at higher risk for severe COVID19 respiratory infection and mortality.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3680.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).