PT - JOURNAL ARTICLE AU - Pierucci, Paola AU - Quaranta, Vitaliano AU - Tummolo, Maria Grazia AU - Portacci, Andrea AU - Di Lecce, Valentina AU - Palumbo, Alessandro AU - Intiglietta, Pier Luigi AU - Carpagnano, Giovanna Elisiana TI - Hypovitaminosis D and severity of COVID19 respiratory infection in a respiratory intensive care unit (RICU) in Apulia southern Italian region AID - 10.1183/13993003.congress-2021.PA3680 DP - 2021 Sep 05 TA - European Respiratory Journal PG - PA3680 VI - 58 IP - suppl 65 4099 - https://publications.ersnet.org//content/58/suppl_65/PA3680.short 4100 - https://publications.ersnet.org//content/58/suppl_65/PA3680.full SO - Eur Respir J2021 Sep 05; 58 AB - Background: The association between severe hypovitaminosis D (<10ng/ml) and the illness course and deaths related to respiratory failure Coronavirus disease 19 (COVID-19) infection has been already described in the literature. The sun exposure is known to be responsible to increase Vit D circulating level.Aims: To compare the severity of COVID-19 disease and death’s rate with Vit D levels among all patients admitted in a RICU in Bari during the first and second wave of infection before and after sun exposure during summer.Methods: Retrospective, observational single centre study of a total of 83 patients admitted to the COVID RICU in Bari between 1.03.2020-30.04.2020 and 1.09.2020-15.11.2020. Patients with moderate to severe Vitamin D deficiency (<20ng/dl) (Group 1; n = 30) were compared with those with Vitamin D> = 20ng/dl (Group 2; n = 83)Results: A Kaplan Meyer survival curve showed that patients in group1 had significantly reduced survival (Log Rank Mantel Cox 6,836; p = 0.009) compared to group 2. Univariate Cox analysis confirmed that Vitamin D values <20 are a risk factor for mortality (HR 6.370); P = 0.022). Multivariate model of COX Vitamin D values <20 increased the predictive capacity with HR of 30.129 (p = 0.008) compared to the HR of 6.370 of the univariate analysis.Conclusions: In this study, in comparison to previous findings, patients with moderate to severe Vitamin D deficiency (<20ng/dl) have been found at higher risk for severe COVID19 respiratory infection and mortality.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3680.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).