PT  - JOURNAL ARTICLE
AU  - Andrea Zapater Matute
AU  - Manuel Sánchez-De-La-Torre
AU  - Alicia Sánchez-De-La-Torre
AU  - Esther Gracia-Lavedan
AU  - Iván David Benítez
AU  - Gerard Torres
AU  - Ferran Barbé
TI  - Respiratory polygraphy patterns and risk of cardiovascular events in patients with acute coronary syndrome
AID  - 10.1183/13993003.congress-2021.PA2489
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA2489
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA2489.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA2489.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Background: Recent studies have suggested that the population with a first event of acute coronary syndrome (ACS) is susceptible to the deleterious effects of obstructive sleep apnea (OSA)(Zapater, A. et al. Am J Respir Crit Care Med 2020; 202:1698-1706).Aim and objectives: We explore respiratory polygraphy parameters that are associated with an increased risk of recurrence cardiovascular events in this subgroup of patients with ACS.Methods: Post-hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087). A principal component analysis (PCA) was performed using six respiratory polygraphy parameters: apnea-hypopnea index (AHI), oxygen desaturation index, mean and minimum oxygen saturation (SaO2), average duration of events and percentage of time with SaO2<90%.Results: PCA showed that two respiratory polygraphy patterns accounted for 70% of variance. A first pattern was mainly characterized by low mean SaO2 and events with severe desaturation (High Time with SaO2<90%) and a second pattern is characterized by high mean SaO2 and longer duration events with severe desaturation (Low Time with SaO2<90%). The Low Time with SaO2<90% pattern was associated with an increased risk of recurrent cardiovascular events with an adjusted HR (95% CI) of 2.44 (1.07 to 5.56; p-value=0.03). For the High Time with SaO2<90% pattern, no significant association was found for the risk of recurrent cardiovascular events.Conclusions: A sleep apnea pattern, mainly characterized by high mean SaO2 and longer duration events with severe desaturation, is associated with a high risk of recurrent cardiovascular events in patients who have suffered a first ACS.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2489.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).