RT Journal Article SR Electronic T1 Awake prone position in hypoxemic Covid 19 Pneumonia: Does it reduce the mortality rate? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA903 DO 10.1183/13993003.congress-2021.PA903 VO 58 IS suppl 65 A1 Islam Mejri Ep Ajili A1 Nouha Guediri A1 Maroua Kacem A1 Samira Mhamdi A1 Selsabil Daboussi A1 Chiraz Aichaouia A1 Zied Moatemri A1 Mohsen Khadhraoui YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/PA903.abstract AB Introduction: The coronavirus disease 2019 (COVID-19) is a pandemic respiratory infection that can worsen rapidly into an acute respiratory distress syndrome (ARDS) in some patients. Prone position is confirmed as a helpful treatment for ARDS within intubated patients. However, some studies have suggested its efficacy in awake patients with ARDS.Aims: to evaluate the impact of awake prone position in patients with COVID-19 pneumonia, hospitalized outside the ICU, on mortality rate.Methods: A prospective evaluative study between September 2020 and February 2021 including 139 confirmed covid-19 patients hospitalized in the pulmonology department of the military hospital of Tunis. Patients were randomly divided into two groups: G1:Prone position (n=38); G2: No Prone Position (n=101).Result: The cohort included 139 patients. There was no difference between the two groups in sex ratio (2.1 vs 2.9), middle age (59.66 vs 62.49);and active smoking (24% vs 38%) respectively for G1 and G2.The most common comorbidities were: Hypertension (47 % vs 36 %), diabetes (15% vs 10%) and chronic obstructive pulmonary disease (0% vs 10%;p=0.04) respectively in G1 and G2. In G1 none of patients were transferred to ICU vs 12% in G2(p=0,033). Prone position patients were associated with decreased mortality rate 3% versus 22% (p=0,02).There were no significant difference between the two groups in main hospital length of stay (p=0.3).Middle arterial saturation of oxygen in supine position was 90% versus 94% in prone position(p<0.001).Conclusion: Prone positioning was effective in decreasing mortality, arterial saturation of oxygen and transfer to ICU in awake patients with COVID-19 requiring oxygen supplementation.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA903.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).