RT Journal Article
SR Electronic
T1 CLE-test with cold air as provocation factor – a feasibility study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3223
DO 10.1183/13993003.congress-2021.PA3223
VO 58
IS suppl 65
A1 Sandra Stadheim
A1 Signe Bø
A1 Ola Drange Røksund
A1 Håkon Kvidaland
A1 Hege Synnøve Clemm
A1 Jon Andrew Hardie
A1 Jon Andrew Hardie
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3223.abstract
AB Introduction: Exercise-induced laryngeal obstruction (EILO) is an important differential diagnosis in exercise-related breathing difficulties. The current gold standard in EILO-diagnostics is the Continuous Laryngoscopy Exercise test (CLE). Although many patients report worsened symptoms during exercise in cold climate, CLE-tests are exclusively performed at room temperature.Aim: We developed a method to investigate if cold air impacts EILO. This study aims to investigate whether having the patient breath cold air (-15⁰C) during CLE-test is feasible and if EILO is aggravated by exercise in cold air.Methods: CLE was used to visualize laryngeal response patterns during two treadmill tests (EIB-protocol 90-95% max. HR over 6 min). Each participant performed two tests at the same speed and incline; one at room temperature and one with cold air from a Turboaire Challenger™ cold air. At 7 Bar pressure, the generator gives 240 l/min at -18°C to -20°C prior to mixing with exhaled breath.Results: Four study participants were included in this study. It was possible to perform the CLE test with simultaneous cold air inhalation. The larynx images were stable and of good quality. The participants reported only minimal discomfort performing the tests. Two participants had a suspected EILO diagnosis before testing. During their cold air test, EILO symptoms seemed to appear earlier in the test with a medialization of laryngeal structures, mainly on the glottic level.Conclusions: The method was feasible and can be used to evaluate whether inhalation of cold air accentuates or quickens the development of EILO. More research is needed.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3223.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).